How to Dial In "In the Blood" by John Mayer - Guitar Tone Settings
Gear for "In the Blood"
Suggested rig · the original isn't documented.
Knob Positions, Pickup, and Tuning
Where to set the knobs for this tone. Each value is on the standard 0–10 amp scale.
On your amp, these numbers won't sound the same.
Get the settings for my ampHow the artist had their guitar configured for this take.
From The Search for Everything (2017). Mayer's long-time guitar is his Fender signature Stratocaster, and he is known for Dumble amps, though no source documents the rig for this song. A signature Strat into a Two-Rock Akoya, a boutique amp in the same clean, glassy family, stands in. Keep the amp clean to just breaking up and use the neck and middle pickups for a warm, glassy tone. Tuning isn't documented here.
Common Questions About the "In the Blood" Tone
What guitar did John Mayer use on "In the Blood"?
The guitar on "In the Blood" (released 2017) isn't documented; the Fender John Mayer Stratocaster (Signature) above gets the sound. Pickup selector: neck + middle (position 2) on the guitar.
What amp settings does "In the Blood" need?
Settings for this sound: Gain 3, Bass 5, Mid 5, Treble 6, Presence 5, Volume 6. Each value is on the standard 0–10 amp scale; match them on your amp first, then nudge to taste. ToneMirror can translate these positions for whatever amp you actually own.
Can I play "In the Blood" without the original gear?
Yes. ToneMirror takes the settings above and adapts it to your guitar, amp, and pedals - so you can chase the "In the Blood" tone on a Katana, a Helix, a tube combo, or anything else. The translation accounts for EQ curve, gain structure, and pickup type so the result actually sounds like the record, not just the same knob numbers on different gear.
More Tones You Can Dial In
Tone references for "In the Blood" by John Mayer are provided for educational use. ToneMirror is not affiliated with the artists or labels referenced.